BPC157

BPC-157 (Body Protection Compound-157, Pentadecapeptide BPC 157)
For research use only. Not for human or veterinary therapeutic use.
## Basic Chemical Information

– Product Name: BPC-157
– CAS Number: 137525-51-0
– Synonyms: PL14736, Bepecin
– Category: Pentadecapeptide (15 amino acids), synthetic, derived from a fragment of the BPC protein found in human gastric juice
– Amino acid sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
– Single-letter sequence: GEPPPGKPADDAGLV
– Molecular formula: \(\boldsymbol{C_{62}H_{98}N_{16}O_{22}}\)
– Molecular weight: 1419.54 Da (free base); commonly available on the market as TFA salt or acetate (be sure to specify the salt form in quotations and COAs)
– Appearance: White to off-white lyophilized powder
– Solubility: Easily soluble in sterile water / bacteriostatically treated water; acid-resistant; good stability in aqueous solution
– Storage: Freeze-dried powder: Store at -20°C in a sealed container protected from light; after reconstitution, store at 2–8°C and use within 7 days; repeated freeze-thaw cycles are prohibited
– Shelf life: 24 months (when stored properly)
## Mechanism of Action in Research
BPC-157 does not bind to a single specific receptor but regulates cells through multiple pathways:

1. Upregulates NO and VEGF, promoting local microvascular angiogenesis and improving microcirculation
2. Downregulates pro-inflammatory factors and scavenges oxygen free radicals, alleviating oxidative stress and local inflammation
3. Regulates the proliferation of fibroblasts and epithelial cells; tissue remodeling effects have been observed in animal models
4. Protects the gastric mucosa and counteracts drug-induced gastrointestinal mucosal damage
5. Neuroprotective effects observed in animal studies

> Research Model Directions (Laboratory research only; not indications)

> – Animal models of tendon, ligament, and skeletal muscle injuries
> – Gastric and intestinal ulcers, intestinal barrier damage
> – Skin wound healing
> – Models of joint and cartilage inflammation
> – Animal studies on peripheral nerve injury