IGF-1 DES (Des (1-3) IGF-1, abbreviated as IGF DES)
> For research use only (in vitro / animal experiments); not a drug; human injection is strictly prohibited; WADA S2-listed prohibited substance
#Basic Information
– CAS: 112603-35-7
– Synonyms: Des (1-3) IGF-1, DES IGF1
– Amino Acids: 67-residue peptide; the first 3 amino acids (Gly-Pro-Glu) at the N-terminus of natural IGF-1 (70 aa) have been removed
– Molecular Weight: 7371.4 Da
– Appearance: White lyophilized powder
– Solubility: Preferably 0.1% acetic acid in deionized water; BAC sterile water is recommended; prone to degradation and inactivation in alkaline environments
Mechanism of Action
Removal of the N-terminal tripeptide directly disrupts the binding site for IGF-binding proteins (IGFBPs):
1. It is virtually not captured by IGFBP, exhibits extremely high free activity, and has a local potency approximately 4–10 times that of full-length native IGF-1
2. Activates IGF-1R and the downstream PI3K/Akt/mTOR and MAPK/ERK signaling pathways
– mTOR: ↑ protein synthesis, inhibition of protein degradation, activation of skeletal muscle satellite cells
– ERK: Cell proliferation, tissue repair
3. Characteristics: Rapid onset of action, short half-life (approximately 20–30 minutes), with a tendency toward localized, targeted effects
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> Research Directions: Localized muscle hypertrophy, skeletal muscle injury repair, neuroprotection, intestinal wound repair, and cell proliferation model studies
Pharmacokinetic Highlights
– Half-life: 20–30 minutes; short duration of action, suitable for localized targeted studies
– Key difference from IGF-1 LR3: DES is **locally acting and short-acting; LR3 is systemically acting and long-acting**
## Reconstitution & Storage (Protein-based; handle gently)
1. Solvent: 0.1% AA acetic acid in water
2. Example: 1 mg lyophilized vial + 1 mL AA water → concentration 1 mg/mL
3. Lyophilized powder: Store sealed and protected from light at -20°C
4. After reconstitution: Aliquot into small portions and store at -20°C; avoid repeated freeze-thaw cycles; refrigerated at 2–8°C for short-term use only (within 1 week)
5. Handling: Add liquid slowly along the wall of the vial; gently roll the vial to dissolve; do not shake vigorously
## Compliance Notice
1. Recombinant protein for research use only; not for human use
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