CJC-1295 with DAC

CJC-1295 with DAC
For research use only
## Basic Chemical Information

– Product Name: CJC-1295 with DAC
– Abbreviation: CJC-1295 DAC
– CAS Number: 446262-90-4 (DAC-modified version; No-DAC version CAS: 863288-34-0—be sure to distinguish between quotes and COAs)
– Full Name: GHRH analog modified with a Drug Affinity Complex (DAC)
– Category: GHRH receptor agonist (growth hormone-releasing hormone analog), 30-amino acid synthetic peptide
– Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys (Maleimidopropionyl)-NH₂
– Molecular formula: \(\boldsymbol{C_{165}H_{269}N_{47}O_{46}}\)
– Molecular weight: 3647.28 Da
– Appearance: White to off-white lyophilized powder
– Solubility: Easily soluble in sterile water
– Storage: Lyophilized powder: Store at -20°C in a sealed container protected from light; after reconstitution, store at 2–8°C and avoid repeated freeze-thaw cycles
– Shelf life: 3 years (when properly stored at -20°C)
– Half-life: 5–8 days (a key feature of the DAC-modified version; the non-DAC version has a half-life of only about 30 minutes)
## Mechanism of Action (Research Hypotheses Only; Promotion of Therapeutic Efficacy Prohibited)
## Research Directions (Laboratory Research Only; Not Indications)

– Basic research on the GH/IGF-1 endocrine pathway
– Pharmacokinetic studies on long-acting peptide-albumin conjugation technology
– Animal models: Research models related to body composition, metabolism, and tissue repair

1. Binds to the GHRH receptor in the anterior pituitary, stimulating sustained secretion of growth hormone (GH) by the pituitary, which in turn upregulates IGF-1
2. DAC covalently binds to albumin, prolonging its residence time in the body and resulting in sustained elevation of GH/IGF-1 levels; this is not a pulsatile release