GHRP-2

GHRP-2 (Pralmorelin, Pralmorelin Acetate)

⚠️ For research use only; approved in Japan as a diagnostic agent for GH deficiency; not a therapeutic drug in other regions; non-medical injection into humans is strictly prohibited; WADA S2 banned substance

Basic Information

– CAS: 158861-67-7

– Aliases: Pralmorelin, KP-102, GPA-748; the acetate form is most common

– Type: Hexapeptide (6aa), contains D-amino acids for proteolytic stability

– Sequence: D-Ala-D-βNal-Ala-Trp-D-Phe-Lys-NH₂

– Molecular formula: \(\boldsymbol{C_{45}H_{55}N_{9}O_{6}}\)

– Molecular weight: 817.97 Da

– Appearance: White lyophilized powder

– Solubility: Easily soluble in BAC bacteriostatic water / AA sterile water

Mechanism of Action

GHRP-2 belongs to the GHS-R1a (ghrelin receptor) agonist class (GHRP growth hormone-releasing peptide family) and targets a completely different receptor from GHRH analogs (Sermorelin/Tesamorelin):

1. Binds to GHS-R1a in the pituitary gland and hypothalamus, powerfully stimulating pulsatile GH release; the intensity of GH release is stronger than that of Ipamorelin

2. Dual action: directly stimulates the pituitary gland to secrete GH; simultaneously inhibits somatostatin, thereby lifting its inhibitory effect on GH

3. It causes a mild increase in cortisol and prolactin; it has an appetite-stimulating effect (weaker than GHRP-6, but far stronger than Ipamorelin)

> Classic research combination: GHRP-2 + GHRH analogs (CJC1295 / Sermorelin); the two exhibit a synergistic effect, significantly amplifying GH release

Pharmacokinetics (for research reference)

– Half-life: Approximately 20–30 minutes after subcutaneous administration

– GH peak: Approximately 15–30 minutes after administration; short pulse release

Reconstitution & Storage (Laboratory Procedures)

1. Solvent: BAC antimicrobial water / AA sterile water

2. Example: 2 mg lyophilized vial + 1 mL BAC water → concentration 2 mg/mL

3. Powder: Store sealed at -20°C, protected from light

4. After reconstitution: Refrigerate at 2–8°C; use within 2–4 weeks; avoid repeated freeze-thaw cycles

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> Tryptophan (Trp) is easily oxidized by light; both the powder and the reconstituted solution must be stored away from light

Compliance Notice

1. Research-grade GHRP-2 is intended solely for in vitro and animal experiments; human injection is prohibited