AOD-9604

AOD-9604 (AOD9604, Advanced Obesity Drug 9604)
⚠️ Important Warning: For laboratory research use only; human use is strictly prohibited.
## Basic Chemical Information

– Product Name: AOD-9604
– CAS Number: 221231-10-3
– Synonyms: Tyr-hGH (177-191), hGH fragment (176-191 derivative)
– Amino Acid Sequence: YLRIVQCRSVEGSCGF (Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe), 16 amino acids
– Structural Features: Intramolecular disulfide bond Cys7 ↔ Cys14, forming a cyclic structure
– Molecular formula: \(\boldsymbol{C_{78}H_{123}N_{23}O_{23}S_2}\)
– Molecular weight of free base: 1815.08 Da; acetate: 1875.13 Da
– Appearance: White to off-white lyophilized powder
– Solubility: Easily soluble in water
– Storage: Lyophilized powder: Store at -20°C in a sealed container protected from light; after reconstitution, store at 2–8°C for short-term use
– Shelf life: 3 years (when properly stored at -20°C)
## Mechanism of Action (Preclinical / In Vitro Research Hypotheses Only)

Does not bind to the growth hormone receptor (GHR) and does not elevate IGF-1 levels; this is the key distinction from full-length HGH

1. Activates the β3-adrenergic receptor in fat cells, stimulating hormone-sensitive lipase (HSL) to promote lipolysis and break down stored triglycerides
2. Inhibits de novo fat synthesis (inhibits lipogenesis)
3. Observations in animal models: Reduces visceral fat; some studies suggest potential applications in cartilage protection and joint repair

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> Note: No approved clinical indications; these are research findings only. Claims regarding fat loss efficacy are not permitted.
## Research Directions (Laboratory / Early Phase I Only)

– Research on fat metabolism and visceral fat regulation
– Basic research on cartilage and joint injury repair
– Animal models related to insulin sensitivity
– Phase I low-dose human trials; half-life of approximately 3 hours