GHRP-6

GHRP-6 (Growth Hormone-Releasing Peptide-6, GHRP-6 Acetate)

⚠️ For research, in vitro, and animal testing only; not a marketed drug; human injection is strictly prohibited; WADA S2 banned substance

> First-generation GHS-R1a agonist in the GHRP family; defining characteristic: strongest appetite-stimulating effect

Basic Information

– CAS: 87616-84-0

– Alias: SKF-110679

– Type: Hexapeptide (6 aa), contains D-amino acids for resistance to enzymatic hydrolysis

– Amino acid sequence: His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂

– Molecular formula: \(\boldsymbol{C_{46}H_{56}N_{12}O_{6}}\)

– Molecular weight: 873.01 Da

– Appearance: White lyophilized powder

– Solubility: Easily soluble in BAC (bacterial-inhibited) water / AA (amino acid) sterile water

> The structure contains tryptophan (Trp), which is sensitive to light; store away from light

## Mechanism of Action

GHRP-6 is a ghrelin receptor (GHS-R1a) agonist; its mechanism of action is independent of GHRH:

1. Activates GHS-R1a in the pituitary and hypothalamus, stimulating pulsatile GH release while simultaneously inhibiting somatostatin

2. Acts on the hypothalamic appetite center; its appetite-stimulating effect is the strongest among the GHRP series

3. Causes a dose-dependent increase in cortisol and prolactin (less selective than Ipamorelin)

4. In the classic synergistic combination of GHRP-6 and GHRH analogs (CJC1295 / Sermorelin), the dual-pathway effect results in a significant amplification of GH release

Research Areas: Studies on feeding behavior, body composition, cardiomyoprotection, fibrosis, and animal models of GH secretion mechanisms

Pharmacokinetics (Research Reference)

– Plasma half-life: 15–60 minutes

– GH peak: Approximately 15–30 minutes after administration; pulsatile release followed by a decline

Reconstitution & Storage (Laboratory Procedures)

1. Solvent: BAC bacteriostatically treated water / AA sterile water

2. Example: 5 mg lyophilized vial + 2 mL BAC water → concentration 2.5 mg/mL

3. Lyophilized powder: Store long-term at -20°C, protected from light and sealed

4. After reconstitution: Refrigerate at 2–8°C; **recommended to use within 2–4 weeks; do not freeze after reconstitution

5. Procedure: Slowly add water along the wall of the vial and gently roll the vial to dissolve; do not shake vigorously, as tryptophan is prone to oxidation; store away from light

Compliance Notice

1. Research-grade GHRP-6 is intended solely for in vitro cell and animal experiments; human use is prohibited