Epithalon

Epithalon (Epitalon, AEDG)

CAS: 307297-39-8

Aliases: Epithalon, pineal tetrapeptide; a synthetic tetrapeptide derived from the natural pineal extract epithalamin, developed by Khavinson

⚠️ For laboratory research only; not intended for human therapeutic use

Basic Information

– Amino acid sequence: H-Ala-Glu-Asp-Gly-OH (AEDG, 4-peptide)

– Molecular formula: \(\mathbf{C_{14}H_{22}N_{4}O_{9}}\)

– Molecular weight: 390.35 Da

– Properties: White/off-white lyophilized powder; highly water-soluble; isoelectric point (pI) ≈ 3.4; acidic peptide

Mechanism of Action (Research Focus)

1. Telomerase activation (upregulation of hTERT): In vitro cellular studies have shown that this peptide activates telomerase, maintains telomere length, and extends cellular replication lifespan; this is the most central area of research for this peptide

2. Pineal Gland – Circadian Rhythm Regulation: Regulates melatonin synthesis, restores circadian rhythm disruptions in aging models, and improves sleep-related outcomes

3. Antioxidant and Immunomodulatory Effects: Upregulates SOD and catalase, reduces oxidative stress; modulates immune cell function

4. Endocrine Regulation: Regulates gonadotropin and cortisol levels; studies on aging-related endocrine decline in animal models

Pharmacokinetic Properties

– Small-molecule short peptide; rapidly cleared from the body with a short half-life

– Administration routes: Subcutaneous or intramuscular injection is commonly used in research; nasal formulations are also being studied

Dissolution and Storage (Laboratory Procedures)

1. Dissolution solvent: BAC water / AA sterile acetic acid solution; inject slowly along the wall of the vial; gently roll to dissolve; do not shake vigorously to avoid foaming

2. Lyophilized powder: Store long-term at -20°C in a dry, light-protected environment; stable for 2+ years; store short-term at 2–8°C

3. Reconstituted solution: Refrigerate at 2–8°C; use within 21–30 days; do not freeze the reconstituted solution, as freeze-thaw cycles will damage the peptide chains

Research Combination Recommendations

– Aging / Circadian Rhythm: Epithalon + Pinealon (EDR) (Khavinson series of bioregulatory short peptides)

– Neurological + Antioxidant: Epithalon + Selank / Semax

– Tissue Repair: May be combined with BPC-157, ARA290

⚠️ Important Notice

1. Epithalon is intended solely for in vitro cellular and animal research; human injection is strictly prohibited.

2. Telomerase activation carries potential risks: Telomerase is highly expressed in tumor cells, and related safety data are limited to preclinical studies; there are no sufficient long-term safety data from human studies.

3. All information is based solely on peptide chemistry and preclinical literature and does not constitute any guidance for human use.